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Chloride channel accessory 4
Symbols CLCA4 ; CaCC; CaCC2
External IDs MGI2139790 HomoloGene40808 GeneCards: CLCA4 Gene
Species Human Mouse
Entrez 22802 99663
Ensembl ENSG00000016602 ENSMUSG00000068547
UniProt Q14CN2 E9QLH0
RefSeq (mRNA) NM_012128 NM_207208
RefSeq (protein) NP_036260 NP_997091
Location (UCSC) Chr 1:
86.55 – 86.58 Mb
Chr 3:
144.95 – 144.98 Mb
PubMed search [1] [2]

Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.[1] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[2]

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  1. ^ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. 
  2. ^ Pawłowski K, Lepistö M, Meinander N; et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. 

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