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Chloride channel CLIC-like 1
Symbols CLCC1 ; MCLC
External IDs MGI2385186 HomoloGene9032 GeneCards: CLCC1 Gene
Species Human Mouse
Entrez 23155 229725
Ensembl ENSG00000121940 ENSMUSG00000027884
UniProt Q96S66 Q99LI2
RefSeq (mRNA) NM_001048210 NM_001177770
RefSeq (protein) NP_001041675 NP_001171241
Location (UCSC) Chr 1:
108.93 – 108.96 Mb
Chr 3:
108.65 – 108.68 Mb
PubMed search [1] [2]

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.[1][2]

The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus. It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.[2]


  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  2. ^ a b Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057. 

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