CLCF1

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CLCF1
Identifiers
Aliases CLCF1, BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6, cardiotrophin-like cytokine factor 1, cardiotrophin like cytokine factor 1
External IDs MGI: 1930088 HomoloGene: 8299 GeneCards: CLCF1
RNA expression pattern
PBB GE CLCF1 219500 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013246
NM_001166212

NM_019952
NM_001310038
NM_001310039

RefSeq (protein)

NP_001159684
NP_037378

Location (UCSC) Chr 11: 67.36 – 67.37 Mb Chr 19: 4.21 – 4.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.[3]

Function[edit]

CLCF1 induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone and IL-6) and serum amyloid A, and in B cell hyperplasia. This cytokine is capable of B cell activation via gp130 receptor stimulation.[4]

Structure[edit]

CLCF1 is a cytokine belonging to the interleukin-6 (IL6) family. It is a secreted protein, found predominantly in lymph nodes and spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1". 
  4. ^ Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J, Elliott G, McNinch J, Shaklee CL, Freeman D, Manu F, Simonet WS, Boone T, Chang MS (September 1999). "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11458–63. doi:10.1073/pnas.96.20.11458. PMC 18055Freely accessible. PMID 10500198. 

Further reading[edit]

External links[edit]