CLCF1 is a cytokine belonging to the interleukin-6 (IL6) family. It is a secreted protein, found predominantly in lymph nodes and spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.
Shi Y, Wang W, Yourey PA, et al. (1999). "Computational EST database analysis identifies a novel member of the neuropoietic cytokine family.". Biochem. Biophys. Res. Commun. 262 (1): 132–8. doi:10.1006/bbrc.1999.1181. PMID10448081.
Elson GC, Lelièvre E, Guillet C, et al. (2000). "CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.". Nat. Neurosci. 3 (9): 867–72. doi:10.1038/78765. PMID10966616.
Lelièvre E, Plun-Favreau H, Chevalier S, et al. (2001). "Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component.". J. Biol. Chem. 276 (25): 22476–84. doi:10.1074/jbc.M101681200. PMID11294841.
Auernhammer CJ, Isele NB, Kopp FB, et al. (2003). "Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3.". Endocrinology. 144 (4): 1202–10. doi:10.1210/en.2002-220933. PMID12639901.
Burger R, Bakker F, Guenther A, et al. (2004). "Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.". Br. J. Haematol. 123 (5): 869–78. doi:10.1046/j.1365-2141.2003.04686.x. PMID14632778.