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Chloride channel, voltage-sensitive 6
Symbols CLCN6 ; CLC-6
External IDs OMIM602726 MGI1347049 HomoloGene985 IUPHAR: 705 GeneCards: CLCN6 Gene
Species Human Mouse
Entrez 1185 26372
Ensembl ENSG00000011021 ENSMUSG00000029016
UniProt P51797 O35454
RefSeq (mRNA) NM_001256959 NM_011929
RefSeq (protein) NP_001243888 NP_036059
Location (UCSC) Chr 1:
11.81 – 11.84 Mb
Chr 4:
148 – 148.04 Mb
PubMed search [1] [2]

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.[1][2]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.[2]

See also[edit]


  1. ^ Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009. 
  2. ^ a b "Entrez Gene: CLCN6 chloride channel 6". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.