CLCNKB

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CLCNKB
Identifiers
Aliases CLCNKB, CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb
External IDs MGI: 1329026 HomoloGene: 65 GeneCards: CLCNKB
RNA expression pattern
PBB GE CLCNKB 205985 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000085
NM_001165945

NM_001146307
NM_024412

RefSeq (protein)

NP_000076
NP_001159417

NP_001139779
NP_077723

Location (UCSC) Chr 1: 16.04 – 16.06 Mb Chr 4: 141.38 – 141.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.[3][4]

Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.[5] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.[6] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.[3]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CLCNKB chloride channel Kb". 
  4. ^ Saito-Ohara F, Uchida S, Takeuchi Y, Sasaki S, Hayashi A, Marumo F, Ikeuchi T (September 1996). "Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization". Genomics. 36 (2): 372–4. PMID 8812470. doi:10.1006/geno.1996.0479. 
  5. ^ Jentsch TJ, Günther W (February 1997). "Chloride channels: an emerging molecular picture". BioEssays. 19 (2): 117–26. PMID 9046241. doi:10.1002/bies.950190206. 
  6. ^ Krämer BK, Bergler T, Stoelcker B, Waldegger S (January 2008). "Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance". Nat Clin Pract Nephrol. 4 (1): 38–46. PMID 18094726. doi:10.1038/ncpneph0689. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.