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Chloride channel, voltage-sensitive Kb
Symbols CLCNKB ; CLCKB; ClC-K2; ClC-Kb
External IDs OMIM602023 MGI1930643 HomoloGene65 IUPHAR: 701 GeneCards: CLCNKB Gene
RNA expression pattern
PBB GE CLCNKB 205985 x at tn.png
PBB GE CLCNKA 207047 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1188 12733
Ensembl ENSG00000184908 ENSMUSG00000033770
UniProt P51801 Q9WUB7
RefSeq (mRNA) NM_000085 NM_001146307
RefSeq (protein) NP_000076 NP_001139779
Location (UCSC) Chr 1:
16.04 – 16.06 Mb
Chr 4:
141.38 – 141.4 Mb
PubMed search [1] [2]

Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.[1][2]

Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.[3] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.[4] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.[1]

See also[edit]


  1. ^ a b "Entrez Gene: CLCNKB chloride channel Kb". 
  2. ^ Saito-Ohara F, Uchida S, Takeuchi Y, Sasaki S, Hayashi A, Marumo F, Ikeuchi T (September 1996). "Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization". Genomics 36 (2): 372–4. doi:10.1006/geno.1996.0479. PMID 8812470. 
  3. ^ Jentsch TJ, Günther W (February 1997). "Chloride channels: an emerging molecular picture". BioEssays 19 (2): 117–26. doi:10.1002/bies.950190206. PMID 9046241. 
  4. ^ Krämer BK, Bergler T, Stoelcker B, Waldegger S (January 2008). "Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance". Nat Clin Pract Nephrol 4 (1): 38–46. doi:10.1038/ncpneph0689. PMID 18094726. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.