Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKBgene.
Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gatedchloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.
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