CLDN11

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CLDN11
Identifiers
Aliases CLDN11, OSP, OTM, claudin 11
External IDs MGI: 106925 HomoloGene: 4093 GeneCards: CLDN11
RNA expression pattern
PBB GE CLDN11 206908 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005602
NM_001185056

NM_008770

RefSeq (protein)

NP_001171985
NP_005593

NP_032796.1
NP_032796

Location (UCSC) Chr 3: 170.42 – 170.86 Mb Chr 3: 31.15 – 31.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene.[3][4][5] It belongs to the group of claudins.

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR, Farber DB (Feb 1997). "Chromosomal localization of murine and human oligodendrocyte-specific protein genes". Genomics. 34 (2): 255–7. doi:10.1006/geno.1996.0278. PMID 8661061. 
  4. ^ Bronstein JM, Popper P, Micevych PE, Farber DB (Nov 1996). "Isolation and characterization of a novel oligodendrocyte-specific protein". Neurology. 47 (3): 772–8. doi:10.1212/wnl.47.3.772. PMID 8797478. 
  5. ^ a b "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)". 

External links[edit]

Further reading[edit]