CLDN18

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CLDN18
Identifiers
Aliases CLDN18, SFTA5, SFTPJ, claudin 18
External IDs MGI: 1929209 HomoloGene: 9489 GeneCards: CLDN18
RNA expression pattern
PBB GE CLDN18 221133 s at fs.png

PBB GE CLDN18 214135 at fs.png

PBB GE CLDN18 221132 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016369
NM_001002026

NM_001194921
NM_001194922
NM_001194923
NM_019815

RefSeq (protein)

NP_001002026
NP_057453

Location (UCSC) Chr 3: 138 – 138.03 Mb Chr 9: 99.69 – 99.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[3] It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[4] [supplied by OMIM][3]

Clinical significance[edit]

Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[5]

Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.[5]

References[edit]

External links[edit]

Further reading[edit]