CLDN19

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CLDN19
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLDN19, HOMG5, claudin 19
External IDs MGI: 3033992 HomoloGene: 17528 GeneCards: 149461
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_148960
NM_001123395
NM_001185117

NM_001038590
NM_153105

RefSeq (protein)

NP_001116867.1
NP_001172046.1
NP_683763.2

NP_001033679.1
NP_694745.1

Location (UCSC) Chr 1: 42.73 – 42.74 Mb Chr 4: 119.26 – 119.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.[1] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.[2][3]

Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM][1]

References[edit]

  1. ^ a b "Entrez Gene: CLDN19 claudin 19". 
  2. ^ Naeem, M.; Hussain, S.; Akhtar, N. (2011). "Mutation in the Tight-Junction Gene Claudin 19 (CLDN19) and Familial Hypomagnesemia, Hypercalciuria, Nephrocalcinosis (FHHNC) and Severe Ocular Disease". American Journal of Nephrology 34 (3): 241–248. doi:10.1159/000330854. PMID 21791920. 
  3. ^ Konrad, M.; Schaller, A.; Seelow, D.; Pandey, A. V.; Waldegger, S.; Lesslauer, A.; Vitzthum, H.; Suzuki, Y.; Luk, J. M.; Becker, C.; Schlingmann, K. P.; Schmid, M.; Rodriguez-Soriano, J.; Ariceta, G.; Cano, F.; Enriquez, R.; Jüppner, H.; Bakkaloglu, S. A.; Hediger, M. A.; Gallati, S.; Neuhauss, S. C. F.; Nürnberg, P.; Weber, S. (2006). "Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement". The American Journal of Human Genetics 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971. 

Further reading[edit]