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AliasesCLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1, claudin 3
External IDsMGI: 1329044 HomoloGene: 1001 GeneCards: CLDN3
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CLDN3
Genomic location for CLDN3
Band7q11.23Start73,768,997 bp[1]
End73,770,270 bp[1]
RNA expression pattern
PBB GE CLDN3 203953 s at fs.png

PBB GE CLDN3 203954 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 73.77 – 73.77 MbChr 5: 134.99 – 134.99 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.[5] It is a member of the claudin protein family.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.[5]


CLDN3 has been shown to interact with CLDN1[6] and CLDN5.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165215 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070473 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: CLDN3 claudin 3".
  6. ^ a b Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588.

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