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Claudin 3
Symbols CLDN3 ; C7orf1; CPE-R2; CPETR2; HRVP1; RVP1
External IDs OMIM602910 MGI1329044 HomoloGene1001 GeneCards: CLDN3 Gene
RNA expression pattern
PBB GE CLDN3 203953 s at tn.png
PBB GE CLDN3 203954 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1365 12739
Ensembl ENSG00000165215 ENSMUSG00000070473
UniProt O15551 Q9Z0G9
RefSeq (mRNA) NM_001306 NM_009902
RefSeq (protein) NP_001297 NP_034032
Location (UCSC) Chr 7:
73.77 – 73.77 Mb
Chr 5:
134.99 – 134.99 Mb
PubMed search [1] [2]

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.[1] It is a member of the claudin protein family.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.[1]


CLDN3 has been shown to interact with CLDN1[2] and CLDN5.[2]


  1. ^ a b "Entrez Gene: CLDN3 claudin 3". 
  2. ^ a b Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588. 

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