From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Aliases CLEC2B, AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B
External IDs HomoloGene: 68443 GeneCards: CLEC2B
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CLEC2B
Genomic location for CLEC2B
Band 12p13.31 Start 9,852,984 bp[1]
End 9,870,136 bp[1]
RNA expression pattern
PBB GE CLEC2B 209732 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 9.85 – 9.87 Mb n/a
PubMed search [2] n/a
View/Edit Human

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.[3][4]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[4]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110852 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA (Mar 1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex". Immunogenetics. 45 (5): 295–300. doi:10.1007/s002510050208. PMID 9038101. 
  4. ^ a b "Entrez Gene: CLEC2B C-type lectin domain family 2, member B". 

External links[edit]

Further reading[edit]