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Protein CLEC4M PDB 1k9j.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDs MGI: 2157942 HomoloGene: 129771 GeneCards: 10332
RNA expression pattern
PBB GE CLEC4M 207995 s at tn.png

PBB GE CLEC4M 210481 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 19: 7.76 – 7.77 Mb Chr 8: 3.74 – 3.75 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.[3] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1-2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769. 
  4. ^ "Entrez Gene: CLEC4M C-type lectin domain family 4, member M". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.