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Chloride intracellular channel 1
Protein CLIC1 PDB 1k0m.png
PDB rendering based on 1k0m.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLIC1 ; G6; NCC27
External IDs OMIM602872 MGI2148924 HomoloGene20343 GeneCards: CLIC1 Gene
RNA expression pattern
PBB GE CLIC1 208659 at tn.png
More reference expression data
Species Human Mouse
Entrez 1192 114584
Ensembl ENSG00000206394 ENSMUSG00000007041
UniProt O00299 Q9Z1Q5
RefSeq (mRNA) NM_001287593 NM_033444
RefSeq (protein) NP_001274522 NP_254279
Location (UCSC) Chr 6:
31.73 – 31.74 Mb
Chr 17:
35.05 – 35.06 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[2]


CLIC1 has been shown to interact with TRAPPC2.[3]

See also[edit]


  1. ^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710. 
  2. ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1". 
  3. ^ Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. (Netherlands) 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.