CLIC1

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Chloride intracellular channel 1
Protein CLIC1 PDB 1k0m.png
PDB rendering based on 1k0m.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CLIC1 ; G6; NCC27
External IDs OMIM602872 MGI2148924 HomoloGene20343 GeneCards: CLIC1 Gene
RNA expression pattern
PBB GE CLIC1 208659 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1192 114584
Ensembl ENSG00000206394 ENSMUSG00000007041
UniProt O00299 Q9Z1Q5
RefSeq (mRNA) NM_001287593 NM_033444
RefSeq (protein) NP_001274522 NP_254279
Location (UCSC) Chr 6:
31.73 – 31.74 Mb
Chr 17:
35.05 – 35.06 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[2]

Interactions[edit]

CLIC1 has been shown to interact with TRAPPC2.[3]

See also[edit]

References[edit]

  1. ^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710. 
  2. ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1". 
  3. ^ Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. (Netherlands) 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.