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Chloride intracellular channel 1
Protein CLIC1 PDB 1k0m.png
PDB rendering based on 1k0m.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLIC1 ; G6; NCC27
External IDs OMIM602872 MGI2148924 HomoloGene20343 GeneCards: CLIC1 Gene
RNA expression pattern
PBB GE CLIC1 208659 at tn.png
More reference expression data
Species Human Mouse
Entrez 1192 114584
Ensembl ENSG00000206394 ENSMUSG00000007041
UniProt O00299 Q9Z1Q5
RefSeq (mRNA) NM_001287593 NM_033444
RefSeq (protein) NP_001274522 NP_254279
Location (UCSC) Chr 6:
31.73 – 31.74 Mb
Chr 17:
35.05 – 35.06 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[2]


CLIC1 has been shown to interact with TRAPPC2.[3]

See also[edit]


  1. ^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710. 
  2. ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1". 
  3. ^ Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. (Netherlands) 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486. 

Further reading[edit]

  • Okubo K, Hori N, Matoba R; et al. (1994). "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression". Nat. Genet. 2 (3): 173–9. doi:10.1038/ng1192-173. PMID 1345164. 
  • Frigerio JM, Berthézène P, Garrido P; et al. (1995). "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing". Hum. Mol. Genet. 4 (1): 37–43. doi:10.1093/hmg/4.1.37. PMID 7711732. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Tulk BM, Edwards JC (1998). "NCC27, a homolog of intracellular Cl channel p64, is expressed in brush border of renal proximal tubule". Am. J. Physiol. 274 (6 Pt 2): F1140–9. PMID 9841507. 
  • Chuang JZ, Milner TA, Zhu M, Sung CH (1999). "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons". J. Neurosci. 19 (8): 2919–28. PMID 10191309. 
  • Ribas G, Neville M, Wixon JL; et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J. Immunol. 163 (1): 278–87. PMID 10384126. 
  • Tonini R, Ferroni A, Valenzuela SM; et al. (2000). "Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells". FASEB J. 14 (9): 1171–8. PMID 10834939. 
  • Harrop SJ, DeMaere MZ, Fairlie WD; et al. (2002). "Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution". J. Biol. Chem. 276 (48): 44993–5000. doi:10.1074/jbc.M107804200. PMID 11551966. 
  • Warton K, Tonini R, Fairlie WD; et al. (2002). "Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1". J. Biol. Chem. 277 (29): 26003–11. doi:10.1074/jbc.M203666200. PMID 11978800. 
  • Shanks RA, Larocca MC, Berryman M; et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479. 
  • Littler DR, Harrop SJ, Fairlie WD; et al. (2004). "The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition". J. Biol. Chem. 279 (10): 9298–305. doi:10.1074/jbc.M308444200. PMID 14613939. 
  • Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin". FEBS J. 274 (24): 6306–6316. doi:10.1111/j.1742-4658.2007.06145.x. PMID 18028448. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.