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Chloride intracellular channel 2
Protein CLIC2 PDB 2PER.png
Rendering based on PDB 2PER​.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLIC2 ; CLIC2b; MRXS32; XAP121
External IDs OMIM300138 HomoloGene48010 GeneCards: CLIC2 Gene
RNA expression pattern
PBB GE CLIC2 213415 at tn.png
More reference expression data
Species Human Mouse
Entrez 1193 n/a
Ensembl ENSG00000155962 n/a
UniProt O15247 n/a
RefSeq (mRNA) NM_001289 n/a
RefSeq (protein) NP_001280 n/a
Location (UCSC) Chr X:
155.28 – 155.33 Mb
PubMed search [1] n/a

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.[2]

See also[edit]


  1. ^ Heiss NS, Poustka A (Nov 1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID 9339381. 
  2. ^ a b "Entrez Gene: CLIC2 chloride intracellular channel 2". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.