CLIC4

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CLIC4
Protein CLIC4 PDB 2ahe.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
External IDs MGI: 1352754 HomoloGene: 8490 GeneCards: 25932
RNA expression pattern
PBB GE CLIC4 201559 s at tn.png

PBB GE CLIC4 201560 at tn.png

PBB GE CLIC4 221881 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013943

NM_013885

RefSeq (protein)

NP_039234.1

NP_038913.1

Location (UCSC) Chr 1: 24.75 – 24.84 Mb Chr 4: 135.21 – 135.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.[1]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).[1]

Binding partners[edit]

CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms.[2]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.