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Chloride intracellular channel 4
Protein CLIC4 PDB 2ahe.png
PDB rendering based on 2ahe.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLIC4 ; CLIC4L; H1; MTCLIC; huH1; p64H1
External IDs OMIM606536 MGI1352754 HomoloGene8490 GeneCards: CLIC4 Gene
RNA expression pattern
PBB GE CLIC4 201560 at tn.png
PBB GE CLIC4 201559 s at tn.png
PBB GE CLIC4 221881 s at tn.png
More reference expression data
Species Human Mouse
Entrez 25932 29876
Ensembl ENSG00000169504 ENSMUSG00000037242
UniProt Q9Y696 Q9QYB1
RefSeq (mRNA) NM_013943 NM_013885
RefSeq (protein) NP_039234 NP_038913
Location (UCSC) Chr 1:
24.75 – 24.84 Mb
Chr 4:
135.21 – 135.27 Mb
PubMed search [1] [2]

Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.[1]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).[1]

Binding partners[edit]

CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms.[2]

See also[edit]


Further reading[edit]

  • Berryman MA, Goldenring JR (2004). "CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells". Cell Motil. Cytoskeleton 56 (3): 159–72. doi:10.1002/cm.10141. PMID 14569596. 
  • Bohman S, Matsumoto T, Suh K; et al. (2006). "Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis". J. Biol. Chem. 280 (51): 42397–404. doi:10.1074/jbc.+M506724200. PMID 16239224. 
  • Chuang JZ, Milner TA, Zhu M, Sung CH (1999). "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons". J. Neurosci. 19 (8): 2919–28. PMID 10191309. 
  • Duncan RR, Westwood PK, Boyd A, Ashley RH (1997). "Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum". J. Biol. Chem. 272 (38): 23880–6. doi:10.1074/jbc.272.38.23880. PMID 9295337. 
  • Edwards JC (1999). "A novel p64-related Cl channel: subcellular distribution and nephron segment-specific expression". Am. J. Physiol. 276 (3 Pt 2): F398–408. PMID 10070163. 
  • Qian Z, Okuhara D, Abe MK, Rosner MR (1999). "Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel". J. Biol. Chem. 274 (3): 1621–7. doi:10.1074/jbc.274.3.1621. PMID 9880541. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Shiio Y, Suh KS, Lee H; et al. (2006). "Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4". J. Biol. Chem. 281 (5): 2750–6. doi:10.1074/jbc.+M509349200. PMID 16316993. 
  • Singh H, Ashley RH (2007). "CLIC4 (p64H1) and its putative transmembrane domain form poorly selective, redox-regulated ion channels". Mol. Memb. Biol. 24 (1): 41–52. doi:10.1080/09687860600927907. PMID 17453412. 
  • Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin". FEBS J. 274 (24): 6306–6316. doi:10.1111/j.1742-4658.2007.06145.x. PMID 18028448. 
  • Valenzuela SM, Martin DK, Por SB; et al. (1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J. Biol. Chem. 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710. 
  • Wick M, Bürger C, Brüsselbach S; et al. (1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell. Sci. 107 (1): 227–39. PMID 8175911. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.