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Chloride intracellular channel 4
Protein CLIC4 PDB 2ahe.png
PDB rendering based on 2ahe.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLIC4 ; CLIC4L; H1; MTCLIC; huH1; p64H1
External IDs OMIM606536 MGI1352754 HomoloGene8490 GeneCards: CLIC4 Gene
RNA expression pattern
PBB GE CLIC4 201560 at tn.png
PBB GE CLIC4 201559 s at tn.png
PBB GE CLIC4 221881 s at tn.png
More reference expression data
Species Human Mouse
Entrez 25932 29876
Ensembl ENSG00000169504 ENSMUSG00000037242
UniProt Q9Y696 Q9QYB1
RefSeq (mRNA) NM_013943 NM_013885
RefSeq (protein) NP_039234 NP_038913
Location (UCSC) Chr 1:
24.75 – 24.84 Mb
Chr 4:
135.21 – 135.27 Mb
PubMed search [1] [2]

Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.[1]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).[1]

Binding partners[edit]

CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms.[2]

See also[edit]


Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.