CLK1

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CLK1
Protein CLK1 PDB 1z57.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLK1, CLK, CLK/STY, STY, CDC like kinase 1
External IDs MGI: 107403 HomoloGene: 101535 GeneCards: CLK1
RNA expression pattern
PBB GE CLK1 214683 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024646
NM_001162407
NM_004071

NM_001042634
NM_009905

RefSeq (protein)

NP_001155879
NP_004062

NP_001036099.1
NP_001036099

Location (UCSC) Chr 2: 200.85 – 200.86 Mb Chr 1: 58.41 – 58.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.[3][4]

Function[edit]

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.[4]

Interactions[edit]

CLK1 has been shown to interact with ASF/SF2.[5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. 
  4. ^ a b "Entrez Gene: CLK1 CDC-like kinase 1". 
  5. ^ Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (Oct 1996). "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. Chem. 271 (40): 24569–75. doi:10.1074/jbc.271.40.24569. PMID 8798720. 
  6. ^ Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863. 

External links[edit]

Further reading[edit]