CLK2

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CLK2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLK2
External IDs MGI: 1098669 HomoloGene: 33303 GeneCards: CLK2
RNA expression pattern
PBB GE CLK2 203229 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291
NM_001294338
NM_001294339
NM_003993

NM_001163432
NM_007712

RefSeq (protein)

NP_001281267
NP_001281268
NP_003984

NP_031738.2
NP_001156904
NP_031738

Location (UCSC) Chr 1: 155.26 – 155.28 Mb Chr 3: 89.16 – 89.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.[3][4][5]

Function[edit]

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Dec 1994). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". Journal of Molecular Biology. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150. 
  4. ^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Oct 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Human Genetics. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. 
  5. ^ a b "Entrez Gene: CLK2 CDC-like kinase 2". 

External links[edit]

Further reading[edit]