CLSPN

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CLSPN
Identifiers
AliasesCLSPN, claspin
External IDsOMIM: 605434 MGI: 2445153 HomoloGene: 11138 GeneCards: CLSPN
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CLSPN
Genomic location for CLSPN
Band1p34.3Start35,720,218 bp[1]
End35,769,978 bp[1]
RNA expression pattern
PBB GE CLSPN 219621 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190481
NM_022111
NM_001330490

NM_175554

RefSeq (protein)

NP_001177410
NP_001317419
NP_071394

NP_780763

Location (UCSC)Chr 1: 35.72 – 35.77 MbChr 4: 126.56 – 126.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claspin is a protein that in humans is encoded by the CLSPN gene.[5][6][7]

Function[edit]

Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.[7]

Interactions[edit]

CLSPN has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092853 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042489 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kumagai A, Dunphy WG (Nov 2000). "Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts". Mol Cell. 6 (4): 839–49. doi:10.1016/S1097-2765(05)00092-4. PMID 11090622.
  6. ^ a b Chini CC, Chen J (Aug 2003). "Human claspin is required for replication checkpoint control". J Biol Chem. 278 (32): 30057–62. doi:10.1074/jbc.M301136200. PMID 12766152.
  7. ^ a b "Entrez Gene: CLSPN claspin homolog (Xenopus laevis)".
  8. ^ Lin SY, Li K, Stewart GS, Elledge SJ (2004). "Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6484–9. doi:10.1073/pnas.0401847101. PMC 404071. PMID 15096610.
  9. ^ a b c Serçin O, Kemp MG (May 2011). "Characterization of functional domains in human Claspin". Cell Cycle. 10 (10): 1599–606. doi:10.4161/cc.10.10.15562. PMC 3127160. PMID 21478680.
  10. ^ Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N (2009). "USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin". J. Cell Biol. 184 (1): 13–9. doi:10.1083/jcb.200807137. PMC 2615094. PMID 19124652.

External links[edit]

Further reading[edit]