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Clathrin, heavy chain (Hc)
Protein CLTC PDB 1b89.png
PDB rendering based on 1b89.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLTC ; CHC; CHC17; CLH-17; CLTCL2; Hc
External IDs OMIM118955 MGI2388633 HomoloGene3572 GeneCards: CLTC Gene
RNA expression pattern
PBB GE CLTC 200614 at tn.png
More reference expression data
Species Human Mouse
Entrez 1213 67300
Ensembl ENSG00000141367 ENSMUSG00000047126
UniProt Q00610 Q68FD5
RefSeq (mRNA) NM_001288653 NM_001003908
RefSeq (protein) NP_001275582 NP_001003908
Location (UCSC) Chr 17:
59.62 – 59.7 Mb
Chr 11:
86.69 – 86.76 Mb
PubMed search [1] [2]

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[1][2]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[3]


CLTC has been shown to interact with PICALM[4] and HGS.[5]

See also[edit]


  1. ^ Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375. 
  2. ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026. 
  3. ^ "Entrez Gene: CLTC clathrin, heavy chain (Hc)". 
  4. ^ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell (UNITED STATES) 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022. 
  5. ^ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. (England) 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.