CMB cold spot
The CMB Cold Spot or WMAP Cold Spot is a region of the sky seen in microwaves that has been found to be unusually large and cold relative to the expected properties of the cosmic microwave background radiation (CMBR). The "Cold Spot" is approximately 70 µK (0.00007 K) colder than the average CMB temperature (approximately 2.7 K), whereas the root mean square of typical temperature variations is only 18 µK.[note 1] At some points, the "cold spot" deviates 140 µK colder than the average CMB temperature.
The radius of the "cold spot" subtends about 5°; it is centered at the galactic coordinate lII = 207.8°, bII = −56.3° (equatorial: α = 03h 15m 05s, δ = −19° 35′ 02″). It is, therefore, in the Southern Celestial Hemisphere, in the direction of the constellation Eridanus.
Typically, the largest fluctuations of the primordial CMB temperature occur on angular scales of about 1°. Thus a cold region as large as the "cold spot" appears very unlikely, given generally accepted theoretical models. Various alternative explanations exist, including a so-called Eridanus Supervoid or Great Void. This would be an extremely large region of the universe, roughly 150 to 300 Mpc or 500 million to one billion light-years across and 6 to 10 billion light years away, at redshift , containing a density of matter much smaller than the average density at that redshift. Such a void would affect the observed CMB via the integrated Sachs–Wolfe effect. If a comparable supervoid did exist, it would be one of the largest structures in the observable universe.
Discovery and significance
In the first year of data recorded by the Wilkinson Microwave Anisotropy Probe (WMAP), a region of sky in the constellation Eridanus was found to be cooler than the surrounding area. Subsequently, using the data gathered by WMAP over 3 years, the statistical significance of such a large, cool region was estimated. The probability of finding a deviation at least as high in Gaussian simulations was found to be 1.85%. Thus it appears unlikely, but not impossible, that the cold spot was generated by the standard mechanism of quantum fluctuations during cosmological inflation, which in most inflationary models gives rise to Gaussian statistics. The cold spot may also, as suggested in the references above, be a signal of non-Gaussian primordial fluctuations.
Some authors called into question the statistical significance of this cold spot.
Possible causes other than primordial temperature fluctuation
One possible explanation of the cold spot is a huge void between us and the primordial CMB. A region cooler than surrounding sightlines can be observed if a large void is present, as such a void would cause an increased cancellation between the "late-time" integrated Sachs–Wolfe effect and the “ordinary” Sachs-Wolfe effect. This effect would be much smaller if dark energy were not stretching the void as photons went through it.
Rudnick et al. found a dip in NVSS galaxy number counts in the direction of the Cold Spot, suggesting the presence of a supervoid. Since then, some additional works have cast doubt on the supervoid explanation. The correlation between the NVSS dip and the Cold Spot was found to be marginal using a more conservative statistical analysis. Also, a direct survey for galaxies in several one-degree-square fields within the Cold Spot found no evidence for a supervoid. However, the supervoid explanation has not been ruled out entirely; it remains intriguing, since supervoids do seem capable of affecting the CMB measurably.
A 2015 study shows the presence of a supervoid that has a radius of 1.8 billion light years and is centered at 3 billion light-years from our galaxy in the direction of the Cold Spot, likely being associated with it. This would make it the largest void detected, and one of the largest structures known.[note 2] Later measurements of the Sachs-Wolfe effect show too its likely existence.
Although large voids are known in the universe, a void would have to be exceptionally vast to explain the cold spot, perhaps 1,000 times larger in volume than expected typical voids. It would be 6 billion–10 billion light-years away and nearly one billion light-years across, and would be perhaps even more improbable to occur in the large-scale structure than the WMAP cold spot would be in the primordial CMB.
A 2017 study  reported surveys showing no evidence that associated voids in the line of sight could have caused the CMB Cold Spot and concluded that it may instead have a primordial origin.
One important thing to confirm or rule out the late time integrated Sachs-Wolfe effect is the mass profile of galaxies in the area as ISW effect is affected by the galaxy bias which depends on the mass profiles and types of galaxies 
A controversial claim by Laura Mersini-Houghton is that it could be the imprint of another universe beyond our own, caused by quantum entanglement between universes before they were separated by cosmic inflation. Laura Mersini-Houghton said, "Standard cosmology cannot explain such a giant cosmic hole" and made the remarkable hypothesis that the WMAP cold spot is "… the unmistakable imprint of another universe beyond the edge of our own." If true, this provides the first empirical evidence for a parallel universe (though theoretical models of parallel universes existed previously). It would also support string theory. The team claims that there are testable consequences for its theory. If the parallel-universe theory is true, there will be a similar void in the Celestial sphere's opposite hemisphere (which New Scientist reported to be in the Southern celestial hemisphere; the results of the New Mexico array study reported it as being in the Northern).
A sophisticated computational analysis (using Kolmogorov complexity) has derived evidence for a north and a south cold spot in the satellite data: "...among the high randomness regions is the southern non-Gaussian anomaly, the Cold Spot, with a stratification expected for the voids. Existence of its counterpart, a Northern Cold Spot with almost identical randomness properties among other low-temperature regions is revealed."
These predictions and others were made prior to the measurements (see Laura Mersini). However, apart from the Southern Cold Spot, the varied statistical methods in general fail to confirm each other regarding a Northern Cold Spot. The 'K-map' used to detect the Northern Cold Spot was noted to have twice the measure of randomness measured in the standard model. The difference is speculated to be caused by the randomness introduced by voids (unaccounted-for voids were speculated to be the reason for the increased randomness above the standard model).
Sensitivity to finding method
The cold spot is mainly anomalous because it stands out compared to the relatively hot ring around it; it is not unusual if one only considers the size and coldness of the spot itself. More technically, its detection and significance depends on using a compensated filter like a Mexican hat wavelet to find it.
- CfA2 Great Wall
- Dark flow
- Great Attractor
- Sloan Great Wall
- Void (astronomy)
- Cosmic microwave background
- Wilkinson Microwave Anisotropy Probe
- List of largest voids
- After the dipole anisotropy, which is due to the Doppler shift of the microwave background radiation due to our peculiar velocity relative to the comoving cosmic rest frame, has been subtracted out. This feature is consistent with the Earth moving at some 627 km/s towards the constellation Virgo.
- A claim by Szapudi et al states that the newly found void is the "largest structure ever identified by humanity". However, another source reports that the largest structure is the supercluster corresponding to the NQ2-NQ4 GRB overdensity at 10 billion light years.
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- Dark Energy and the Imprint of Super-Structures on the Microwave Background
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Another explanation could be that the Cold Spot is the remnant of a collision between our Universe and another ‘bubble’ universe during an early inflationary phase (Chang et al. 2009, Larjo & Levi 2010).
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- Great Void in Eridanus, (WMAP Cold Spot)
- Gaping Hole Found in Universe, Daily Tech
- Huge Hole Found in the Universe, Space.com, 2007-08-23
- Gaping "Hole" in the Sky Found, Experts Say, National Geographic News
- BBC News: Great 'cosmic nothingness' found. BBC News, 2007-08-24