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Protein CNOT7 PDB 2d5r.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CNOT7, CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7
External IDs MGI: 1298230 HomoloGene: 49011 GeneCards: CNOT7
RNA expression pattern
PBB GE CNOT7 218250 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 8: 17.22 – 17.25 Mb Chr 8: 40.49 – 40.52 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.[3][4][5][6]


The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[6]


CNOT7 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560Freely accessible. PMID 10637334. 
  4. ^ Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749. 
  5. ^ Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell. Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152. 
  6. ^ a b "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7". 
  7. ^ Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 ( Pt 2): 471–81. PMC 1219893Freely accessible. PMID 9820826. 
  8. ^ Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725. 
  9. ^ a b Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979Freely accessible. PMID 18056425. 
  10. ^ a b Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502. 

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