COASY

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COASY
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COASY, DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2, Coenzyme A synthase
External IDs MGI: 1918993 HomoloGene: 11889 GeneCards: COASY
RNA expression pattern
PBB GE COASY 201913 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042529
NM_001042530
NM_001042531
NM_001042532
NM_025233

NM_027896
NM_001305982

RefSeq (protein)

NP_001035994
NP_001035997
NP_079509

NP_001292911.1
NP_001292911

Location (UCSC) Chr 17: 42.56 – 42.57 Mb Chr 11: 101.08 – 101.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.[3][4][5]


Interactions[edit]

COASY has been shown to interact with P70-S6 Kinase 1.[6] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A (Jun 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". J Biol Chem. 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312. 
  4. ^ Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (Jun 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". J Biol Chem. 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892. 
  5. ^ "Entrez Gene: COASY Coenzyme A synthase". 
  6. ^ Nemazanyy, Ivan; Panasyuk Ganna; Zhyvoloup Alexander; Panayotou George; Gout Ivan T; Filonenko Valeriy (Dec 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. Netherlands. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. ISSN 0014-5793. PMID 15589845. 
  7. ^ Breus, Oksana; Panasyuk G; Gout IT; Filonenko V; Nemazanyy I (May 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway.". Biochem Biophys Res Commun. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007. 

External links[edit]

Further reading[edit]