Collagen, type XV, alpha 1

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COL15A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOL15A1, collagen type XV alpha 1 chain
External IDsMGI: 88449 HomoloGene: 1396 GeneCards: COL15A1
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for COL15A1
Genomic location for COL15A1
Band9q22.33Start98,943,179 bp[1]
End99,070,792 bp[1]
RNA expression pattern
PBB GE COL15A1 203477 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001855

NM_009928

RefSeq (protein)

NP_001846

NP_034058

Location (UCSC)Chr 9: 98.94 – 99.07 MbChr 4: 47.21 – 47.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1 gene.[5][6]

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204291 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028339 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Huebner K, Cannizzaro LA, Jabs EW, Kivirikko S, Manzone H, Pihlajaniemi T, Myers JC (Dec 1992). "Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22". Genomics. 14 (2): 220–4. doi:10.1016/S0888-7543(05)80209-5. PMID 1427836. 
  6. ^ a b "Entrez Gene: COL15A1 collagen, type XV, alpha 1". 

Further reading[edit]