Collagen, type XXV, alpha 1

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COL25A1
Identifiers
AliasesCOL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDsMGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for COL25A1
Genomic location for COL25A1
Band4q25Start108,808,725 bp[1]
End109,302,752 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256074
NM_032518
NM_198721

NM_001244952
NM_029838
NM_198711

RefSeq (protein)

NP_001243003
NP_115907
NP_942014

NP_001231881
NP_084114
NP_942004

Location (UCSC)Chr 4: 108.81 – 109.3 MbChr 3: 130.13 – 130.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[5][6]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][6]

Interactions[edit]

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[5]

References[edit]

Further reading[edit]