COQ2

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COQ2
Identifiers
AliasesCOQ2, CL640, COQ10D1, MSA1, PHB:PPT, coenzyme Q2, polyprenyltransferase
External IDsOMIM: 609825 MGI: 1919133 HomoloGene: 69192 GeneCards: COQ2
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for COQ2
Genomic location for COQ2
Band4q21.22-q21.23Start83,261,536 bp[1]
End83,284,914 bp[1]
RNA expression pattern
PBB GE COQ2 213379 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015697
NM_001358921

NM_027978

RefSeq (protein)

NP_056512
NP_001345850

NP_082254

Location (UCSC)Chr 4: 83.26 – 83.28 MbChr 5: 100.65 – 100.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Para-hydroxybenzoate—polyprenyltransferase, mitochondrial is an enzyme that in humans is encoded by the COQ2 gene.[5][6]

CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004).[supplied by OMIM][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173085 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029319 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Forsgren M, Attersand A, Lake S, Grunler J, Swiezewska E, Dallner G, Climent I (Aug 2004). "Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ". Biochem J. 382 (Pt 2): 519–26. doi:10.1042/BJ20040261. PMC 1133808. PMID 15153069.
  6. ^ a b "Entrez Gene: COQ2 coenzyme Q2 homolog, prenyltransferase (yeast)".

External links[edit]

Further reading[edit]