COTL1

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COTL1
Protein COTL1 PDB 1t2l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COTL1, CLP, coactosin like F-actin binding protein 1
External IDs MGI: 1919292 HomoloGene: 10898 GeneCards: COTL1
RNA expression pattern
PBB GE COTL1 221059 s at fs.png

PBB GE COTL1 gnf1h03101 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021149

NM_028071

RefSeq (protein)

NP_066972

NP_082347.1
NP_082347

Location (UCSC) Chr 16: 84.57 – 84.62 Mb Chr 8: 119.81 – 119.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Coactosin-like protein (COTL1 or CLP) is a protein that in humans is encoded by the COTL1 gene.[3][4][5][6]

Function[edit]

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with and thereby stabilizes 5-lipoxygenase (ALOX5). Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.[6]

Interactions[edit]

COTL1 has been shown to interact with ALOX5.[7] ALOX5 is the first committed enzyme in the metabolism of arachidonic acid to an array of biologically important cell signaling agents: a) the pro-inflammatory mediator, leukotriene B4 (LTB4); b) the airways constrictors, LTC4, LTD4, and LTE4; c) the 5-hydroxyeicosatetraenoic acid family of pro-inflammatory and pro-allergic reactions mediators, 5-HETE and 5-oxo-eicosatetraenoic acid. ALOX5 also contributes to the metabolism of arachidonic acid and other polyunsaturated fatty acids to agents which act block inflammation and allergic reactions, the specialized pro-resolving mediators of the lipoxin and resolvin subclasses. Based on in vitro studies, COTL1 serves to stabilize ALOX5, acting as a chaperone or scaffold, to avert the enzyme's inactivation and thereby to promote its metabolic activity.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Provost P, Samuelsson B, Rådmark O (Apr 1999). "Interaction of 5-lipoxygenase with cellular proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. doi:10.1073/pnas.96.5.1881. PMC 26705Freely accessible. PMID 10051563. 
  4. ^ Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR (Nov 1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome". Nat. Genet. 17 (2): 154–63. doi:10.1038/ng1097-154. PMID 9326934. 
  5. ^ Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O (Sep 2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150–5. doi:10.1073/pnas.0605150103. PMC 1559768Freely accessible. PMID 16924104. 
  6. ^ a b "Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)". 
  7. ^ Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (May 2001). "5-Lipoxygenase interacts with coactosin-like protein". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527. 
  8. ^ Anwar Y, Sabir JS, Qureshi MI, Saini KS (2014). "5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation". Current Drug Targets. 15 (4): 410–22. doi:10.2174/1389450114666131209110745. PMID 24313690. 

External links[edit]

Further reading[edit]