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Cytochrome c oxidase subunit VIc
Symbol COX6C
External IDs OMIM124090 MGI104614 HomoloGene3220 GeneCards: COX6C Gene
EC number
RNA expression pattern
PBB GE COX6C 201754 at tn.png
More reference expression data
Species Human Mouse
Entrez 1345 12864
Ensembl ENSG00000164919 ENSMUSG00000014313
UniProt P09669 Q9CPQ1
RefSeq (mRNA) NM_004374 NM_053071
RefSeq (protein) NP_004365 NP_444301
Location (UCSC) Chr 8:
100.89 – 100.91 Mb
Chr 15:
35.93 – 35.94 Mb
PubMed search [1] [2]

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.[1][2]

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.[2]


  1. ^ Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 226–7. doi:10.1159/000015185. PMID 10072584. 
  2. ^ a b "Entrez Gene: COX6C cytochrome c oxidase subunit VIc". 

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