CP-94253 is a drug which acts as a potent and selective serotonin5-HT1Breceptoragonist, with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain; reducing food intake and promoting satiety; enhancing the reinforcing effects of cocaine; and possible antidepressant effects.
^Koe KB, Nielsen JA, Macor JE, Heym J (1992). "Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253". Drug Development Research. 26 (3): 241–250. doi:10.1002/ddr.430260305. S2CID85358992.
^Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (March 2007). "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology. 559 (2–3): 165–72. doi:10.1016/j.ejphar.2006.12.012. PMID17291490.
^Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports. 60 (6): 798–810. PMID19211971.
^Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E (May 2005). "Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action". European Journal of Pharmacology. 516 (1): 46–50. doi:10.1016/j.ejphar.2005.04.025. PMID15913599.