CPNE1

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
CPNE1
Identifiers
AliasesCPNE1, COPN1, CPN1, copine 1
External IDsMGI: 2386621 HomoloGene: 36501 GeneCards: CPNE1
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for CPNE1
Genomic location for CPNE1
Band20q11.22Start35,626,031 bp[1]
End35,664,956 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170588
NM_170590

RefSeq (protein)

NP_733467
NP_733469

Location (UCSC)Chr 20: 35.63 – 35.66 MbChr 2: 156.07 – 156.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Copine-1 is a protein that in humans is encoded by the CPNE1 gene.[5][6]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214078 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074643 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem. 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674. 
  6. ^ a b "Entrez Gene: CPNE1 copine I". 

External links[edit]

Further reading[edit]