CPSF1

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CPSF1
Identifiers
Aliases CPSF1, CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1
External IDs MGI: 2679722 HomoloGene: 40865 GeneCards: CPSF1
RNA expression pattern
PBB GE CPSF1 201638 s at fs.png

PBB GE CPSF1 201639 s at fs.png

PBB GE CPSF1 33132 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013291

NM_001164173
NM_053193

RefSeq (protein)

NP_037423

NP_001157645.1
NP_444423.1
NP_001157645
NP_444423

Location (UCSC) Chr 8: 144.39 – 144.41 Mb Chr 15: 76.6 – 76.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.[3][4][5]

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1, and located in the nucleus. CPSF1 recognizes the AAUAAA sequence leading to addition of poly(A) to the 3-prime end of the mRNA.[6]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jenny A, Keller W (Sep 1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor". Nucleic Acids Res. 23 (14): 2629–35. doi:10.1093/nar/23.14.2629. PMC 307085Freely accessible. PMID 7651824. 
  4. ^ Murthy KG, Manley JL (Dec 1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244. 
  5. ^ "Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa". 
  6. ^ Yang Q, Doublié S (2011). "Structural biology of poly(A) site definition". Wiley Interdiscip Rev RNA. 2 (5): 723–747. doi:10.1002/wrna.88. PMC 3153407Freely accessible. PMID 21823232. 

External links[edit]

Further reading[edit]