CPSF4

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CPSF4
Protein CPSF4 PDB 2d9n.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CPSF4, CPSF30, NAR, NEB1, NEB-1, cleavage and polyadenylation specific factor 4
External IDs MGI: 1861602 HomoloGene: 38216 GeneCards: CPSF4
RNA expression pattern
PBB GE CPSF4 206688 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081559
NM_006693
NM_001318160
NM_001318161
NM_001318162

NM_001291248
NM_001291249
NM_178576

RefSeq (protein)

NP_001075028
NP_001305089
NP_001305090
NP_001305091
NP_006684

Location (UCSC) Chr 7: 99.44 – 99.46 Mb Chr 5: 145.17 – 145.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.[3][4][5]

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nemeroff ME, Barabino SM, Li Y, Keller W, Krug RM (Jul 1998). "Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs". Mol Cell. 1 (7): 991–1000. doi:10.1016/S1097-2765(00)80099-4. PMID 9651582. 
  4. ^ Barabino SM, Hubner W, Jenny A, Minvielle-Sebastia L, Keller W (Aug 1997). "The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins". Genes Dev. 11 (13): 1703–16. doi:10.1101/gad.11.13.1703. PMID 9224719. 
  5. ^ a b "Entrez Gene: CPSF4 cleavage and polyadenylation specific factor 4, 30kDa". 

Further reading[edit]