CPSF6

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CPSF6
Protein CPSF6 PDB 3P5T.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CPSF6, CFIM, CFIM68, HPBRII-4, HPBRII-7, cleavage and polyadenylation specific factor 6, CFIM72
External IDs MGI: 1913948 HomoloGene: 134126 GeneCards: CPSF6
RNA expression pattern
PBB GE CPSF6 202469 s at fs.png

PBB GE CPSF6 202470 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300947
NM_007007

NM_001013391
NM_001310609

RefSeq (protein)

NP_001287876
NP_008938

NP_001013409.1
NP_001013409
NP_001297538

Location (UCSC) Chr 12: 69.24 – 69.27 Mb Chr 10: 117.34 – 117.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.[5]

Interactions[edit]

CPSF6 has been shown to interact with WWP1[6] and PLSCR1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rüegsegger U, Blank D, Keller W (Jan 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Molecular Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921. 
  4. ^ Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino SM (Apr 2007). "Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit". Molecular Biology of the Cell. 18 (4): 1282–92. doi:10.1091/mbc.E06-09-0846. PMC 1838998Freely accessible. PMID 17267687. 
  5. ^ a b "Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa". 
  6. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

External links[edit]

Further reading[edit]