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PBB Protein CREB1 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CREB1, CREB, CREB-1, cAMP responsive element binding protein 1
External IDs MGI: 88494 HomoloGene: 3223 GeneCards: 1385
RNA expression pattern
PBB GE CREB1 204312 x at tn.png

PBB GE CREB1 204313 s at tn.png

PBB GE CREB1 204314 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 207.53 – 207.6 Mb Chr 1: 64.53 – 64.6 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.[3][4] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[5]

See also[edit]


CREB1 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science. 242 (4884): 1430–3. doi:10.1126/science.2974179. PMID 2974179. 
  4. ^ Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (Jul 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics. 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID 2142119. 
  5. ^ "Entrez Gene: CREB1 cAMP responsive element binding protein 1". 
  6. ^ Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB (Jun 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Molecular and Cellular Biology. 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. PMC 156132free to read. PMID 12773552. 
  7. ^ Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS (Apr 2004). "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 5898–903. doi:10.1073/pnas.0307718101. PMC 395895free to read. PMID 15073328. 
  8. ^ Kim J, Jia L, Stallcup MR, Coetzee GA (Feb 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". Journal of Molecular Endocrinology. 34 (1): 107–18. doi:10.1677/jme.1.01701. PMID 15691881. 
  9. ^ Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". The Journal of Biological Chemistry. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317. 
  10. ^ Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (Dec 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell. 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. PMID 9413984. 
  11. ^ Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". The Journal of Biological Chemistry. 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. PMID 9786917. 
  12. ^ Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (Nov 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". The Journal of Biological Chemistry. 277 (44): 42241–8. doi:10.1074/jbc.M207361200. PMID 12196545. 
  13. ^ a b Giebler HA, Lemasson I, Nyborg JK (Jul 2000). "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Molecular and Cellular Biology. 20 (13): 4849–58. doi:10.1128/MCB.20.13.4849-4858.2000. PMC 85936free to read. PMID 10848610. 
  14. ^ Zhang Q, Vo N, Goodman RH (Jul 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and Cellular Biology. 20 (14): 4970–8. doi:10.1128/MCB.20.14.4970-4978.2000. PMC 85947free to read. PMID 10866654. 
  15. ^ Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (Apr 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. PMC 86859free to read. PMID 11259575. 
  16. ^ Ledo F, Kremer L, Mellström B, Naranjo JR (Sep 2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". The EMBO Journal. 21 (17): 4583–92. doi:10.1093/emboj/cdf440. PMC 126180free to read. PMID 12198160. 
  17. ^ a b c Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166free to read. PMID 11046156. 
  18. ^ Gavaravarapu S, Kamine J (Mar 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and Biophysical Research Communications. 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. PMID 10720489. 
  19. ^ Deak M, Clifton AD, Lucocq LM, Alessi DR (Aug 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775free to read. PMID 9687510. 
  20. ^ Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (Aug 2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMC 125559free to read. PMID 11500364. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.