CREG1

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CREG1
Protein CREG1 PDB 1xhn.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCREG1, CREG, cellular repressor of E1A stimulated genes 1
External IDsMGI: 1344382 HomoloGene: 31199 GeneCards: CREG1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CREG1
Genomic location for CREG1
Band1q24.2Start167,529,677 bp[1]
End167,553,767 bp[1]
RNA expression pattern
PBB GE CREG1 201200 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003851

NM_011804

RefSeq (protein)

NP_003842

NP_035934

Location (UCSC)Chr 1: 167.53 – 167.55 MbChr 1: 165.76 – 165.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein CREG1 is a protein that in humans is encoded by the CREG1 gene.[5][6]

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.[6]

References[edit]

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