CRISP1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CRISP1
Identifiers
Aliases CRISP1, AEGL1, ARP, CRISP-1, HSCRISP1D, HSCRISP1G, HUMARP, HEL-S-57, cysteine rich secretory protein 1
External IDs MGI: 1925331 HomoloGene: 81683 GeneCards: CRISP1
RNA expression pattern
PBB GE CRISP1 207032 s at fs.png

PBB GE CRISP1 216314 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001131
NM_001205220
NM_170609

NM_030033
NM_001347047
NM_001347048

RefSeq (protein)

NP_001122
NP_001192149
NP_733758

n/a

Location (UCSC) Chr 6: 49.83 – 49.88 Mb Chr 1: 18.12 – 18.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine-rich secretory protein 1 is a cysteine-rich secretory protein that in humans is encoded by the CRISP1 gene.[3][4]

Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. This protein is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head where it plays a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface. Two isoforms are encoded by transcript variants of this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hayashi M, Fujimoto S, Takano H, Ushiki T, Abe K, Ishikura H, Yoshida MC, Kirchhoff C, Ishibashi T, Kasahara M (Feb 1997). "Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1)". Genomics. 32 (3): 367–74. doi:10.1006/geno.1996.0131. PMID 8838800. 
  4. ^ a b "Entrez Gene: CRISP1 cysteine-rich secretory protein 1". 

External links[edit]

Further reading[edit]