Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. This protein is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head where it plays a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface. Two isoforms are encoded by transcript variants of this gene.
^Hayashi M, Fujimoto S, Takano H, Ushiki T, Abe K, Ishikura H, Yoshida MC, Kirchhoff C, Ishibashi T, Kasahara M (Feb 1997). "Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1)". Genomics. 32 (3): 367–74. doi:10.1006/geno.1996.0131. PMID8838800.
Evans JP (2003). "The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization.". Hum. Reprod. Update. 8 (4): 297–311. doi:10.1093/humupd/8.4.297. PMID12206465.
Hayashi M (1996). "[Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization]". Hokkaido Igaku Zasshi. 70 (5): 743–53. PMID8543280.
Krätzschmar J, Haendler B, Eberspaecher U, et al. (1996). "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.". Eur. J. Biochem. 236 (3): 827–36. doi:10.1111/j.1432-1033.1996.t01-1-00827.x. PMID8665901.
Cohen DJ, Ellerman DA, Busso D, et al. (2001). "Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg.". Biol. Reprod. 65 (4): 1000–5. doi:10.1095/biolreprod65.4.1000. PMID11566719.