Adapter molecule crk

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Protein CRK PDB 1b07.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CRK, CRKII, p38, v-crk avian sarcoma virus CT10 oncogene homolog, CRK proto-oncogene, adaptor protein
External IDs OMIM: 164762 MGI: 88508 HomoloGene: 81850 GeneCards: CRK
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CRK
Genomic location for CRK
Band 17p13.3 Start 1,420,689 bp[1]
End 1,463,162 bp[1]
RNA expression pattern
PBB GE CRK 202224 at fs.png

PBB GE CRK 202226 s at fs.png

PBB GE CRK 202225 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 1.42 – 1.46 Mb Chr 11: 75.68 – 75.71 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene.[5]

The CRK protein participates in the Reelin signaling cascade downstream of DAB1.[6][7]


Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.[8]

Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.[6][7]

v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.[9] The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.[10]

Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.


CRK (gene) has been shown to interact with:

See also[edit]

  • CrkL, "Crk-like" protein


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167193 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017776 - Ensembl, May 2017
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  4. ^ "Mouse PubMed Reference:". 
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Further reading[edit]

External links[edit]