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Collapsin response mediator protein 1
Protein CRMP1 PDB 1kcx.png
PDB rendering based on 1kcx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CRMP1 ; CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3
External IDs OMIM602462 MGI107793 HomoloGene20347 GeneCards: CRMP1 Gene
RNA expression pattern
PBB GE CRMP1 202517 at tn.png
More reference expression data
Species Human Mouse
Entrez 1400 12933
Ensembl ENSG00000072832 ENSMUSG00000029121
UniProt Q14194 P97427
RefSeq (mRNA) NM_001014809 NM_001136058
RefSeq (protein) NP_001014809 NP_001129530
Location (UCSC) Chr 4:
5.75 – 5.89 Mb
Chr 5:
37.24 – 37.29 Mb
PubMed search [1] [2]

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.[1]

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.[1]

CRMP1 mediates reelin signaling in cortical neuronal migration.[2] Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.[3]

CRMP1 gene overlaps with another gene called EVC.[4]


CRMP1 has been shown to interact with DPYSL2.[5]


  1. ^ a b "Entrez Gene: CRMP1 collapsin response mediator protein 1". 
  2. ^ Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y (December 2006). "Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration". J. Neurosci. 26 (51): 13357–62. doi:10.1523/JNEUROSCI.4276-06.2006. PMID 17182786. 
  3. ^ Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW (March 2007). "Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory". J. Neurosci. 27 (10): 2513–24. doi:10.1523/JNEUROSCI.4497-06.2007. PMID 17344389. 
  4. ^ Ruiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J (March 2000). "Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis". Nat. Genet. 24 (3): 283–6. doi:10.1038/73508. PMID 10700184. 
  5. ^ Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. (Netherlands) 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610. 

Further reading[edit]