CRSP3

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MED23
Identifiers
Aliases MED23, ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2, mediator complex subunit 23
External IDs MGI: 1917458 HomoloGene: 3552 GeneCards: MED23
RNA expression pattern
PBB GE CRSP3 218846 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270521
NM_001270522
NM_004830
NM_015979

NM_001166416
NM_027347

RefSeq (protein)

NP_001257450
NP_001257451
NP_004821
NP_057063

NP_001159888.1
NP_081623.3
NP_001159888
NP_081623

Location (UCSC) Chr 6: 131.57 – 131.63 Mb Chr 10: 24.87 – 24.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.[3][4]

Function[edit]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[4]

Interactions[edit]

CRSP3 has been shown to interact with Estrogen receptor alpha,[5] CEBPB[6] and Cyclin-dependent kinase 8.[5][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412. 
  4. ^ a b "Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa". 
  5. ^ a b Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401Freely accessible. PMID 11867769. 
  6. ^ Mo X, Kowenz-Leutz E, Xu H, Leutz A (Jan 2004). "Ras induces mediator complex exchange on C/EBP beta". Molecular Cell. 13 (2): 241–50. doi:10.1016/S1097-2765(03)00521-5. PMID 14759369. 
  7. ^ Wang G, Cantin GT, Stevens JL, Berk AJ (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Molecular and Cellular Biology. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123Freely accessible. PMID 11416138. 

External links[edit]

Further reading[edit]