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Protein CRYBB1 PDB 1oki.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CRYBB1, CATCN3, CTRCT17, crystallin beta B1
External IDs MGI: 104992 HomoloGene: 1423 GeneCards: CRYBB1
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CRYBB1
Genomic location for CRYBB1
Band 22q12.1 Start 26,599,278 bp[1]
End 26,618,088 bp[1]
RNA expression pattern
PBB GE CRYBB1 206185 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 22: 26.6 – 26.62 Mb Chr 5: 112.26 – 112.27 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Beta-crystallin B1 is a protein that in humans is encoded by the CRYBB1 gene.[5][6][7]

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100122 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029343 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hulsebos TJ, Gilbert DJ, Delattre O, Smink LJ, Dunham I, Westerveld A, Thomas G, Jenkins NA, Copeland NG (Mar 1996). "Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5". Genomics. 29 (3): 712–8. doi:10.1006/geno.1995.9947. PMID 8575764. 
  6. ^ Mackay DS, Boskovska OB, Knopf HL, Lampi KJ, Shiels A (Oct 2002). "A nonsense mutation in CRYBB1 associated with autosomal dominant cataract linked to human chromosome 22q". Am J Hum Genet. 71 (5): 1216–21. doi:10.1086/344212. PMC 385100Freely accessible. PMID 12360425. 
  7. ^ a b "Entrez Gene: CRYBB1 crystallin, beta B1". 

External links[edit]

Further reading[edit]