CRYBB3

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CRYBB3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CRYBB3, CATCN2, CRYB3, CTRCT22, crystallin beta B3
External IDs MGI: 102717 HomoloGene: 3008 GeneCards: CRYBB3
RNA expression pattern
PBB GE CRYBB3 207685 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004076

NM_001159650
NM_021352

RefSeq (protein)

NP_004067

NP_001153122.1
NP_067327.1
NP_001153122
NP_067327

Location (UCSC) Chr 22: 25.2 – 25.21 Mb Chr 5: 113.08 – 113.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Beta-crystallin B3 is a protein that in humans is encoded by the CRYBB3 gene.[3][4]

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lampi KJ, Ma Z, Shih M, Shearer TR, Smith JB, Smith DL, David LL (Feb 1997). "Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens". J Biol Chem. 272 (4): 2268–75. doi:10.1074/jbc.272.4.2268. PMID 8999933. 
  4. ^ a b "Entrez Gene: CRYBB3 crystallin, beta B3". 

Further reading[edit]