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Available structures
PDBOrtholog search: PDBe RCSB
AliasesCRYGC, CCL, CRYG3, CTRCT2, crystallin gamma C
External IDsOMIM: 123680 MGI: 88523 HomoloGene: 36281 GeneCards: CRYGC
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CRYGC
Genomic location for CRYGC
Band2q33.3Start208,128,137 bp[1]
End208,129,828 bp[1]
RNA expression pattern
PBB GE CRYGC 207531 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 208.13 – 208.13 MbChr 1: 65.07 – 65.07 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Crystallin, gamma C, also known as CRYGC, is a protein which in humans is encoded by the CRYGC gene.[5][6]


Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.[6]


CRYGC has been shown to interact with CRYBB2,[7] CRYAA[7] and CRYAB.[7]


  1. ^ a b c ENSG00000285011 GRCh38: Ensembl release 89: ENSG00000163254, ENSG00000285011 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025952 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ den Dunnen JT, Moormann RJ, Cremers FP, Schoenmakers JG (1985). "Two human gamma-crystallin genes are linked and riddled with Alu-repeats". Gene. 38 (1–3): 197–204. doi:10.1016/0378-1119(85)90218-5. PMID 4065573.
  6. ^ a b "Entrez Gene: CRYGC crystallin, gamma C".
  7. ^ a b c Fu L, Liang JJ (February 2002). "Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay". The Journal of Biological Chemistry. 277 (6): 4255–60. doi:10.1074/jbc.M110027200. PMID 11700327.

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