CRYL1

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Crystallin, lambda 1 is a protein that in humans is encoded by the CRYL1 gene. [1]

Function[edit]

The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF160216.1, AK024041.1 [ECO:0000332] RNAseq introns  :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END##

References[edit]

  1. ^ "Entrez Gene: Crystallin, lambda 1". Retrieved 2014-02-21. 

Further reading[edit]

  • Mulders, J. W.; Hendriks, W; Blankesteijn, W. M.; Bloemendal, H; De Jong, W. W. (1988). "Lambda-crystallin, a major rabbit lens protein, is related to hydroxyacyl-coenzyme a dehydrogenases". The Journal of Biological Chemistry. 263 (30): 15462–6. PMID 3170592. 
  • Ishikura, S; Usami, N; Araki, M; Hara, A (2005). "Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase". Journal of Biochemistry. 137 (3): 303–14. doi:10.1093/jb/mvi033. PMID 15809331. 
  • Chen, J; Yu, L; Li, D; Gao, Q; Wang, J; Huang, X; Bi, G; Wu, H; Zhao, S (2003). "Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians". Gene. 302 (1–2): 103–13. doi:10.1016/s0378-1119(02)01095-8. PMID 12527201. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.