CSNK1E

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CSNK1E
Identifiers
Aliases
External IDs GeneCards: [1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC) n/a n/a
PubMed search n/a n/a
Wikidata
View/Edit Human

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.[1][2]

Function[edit]

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[3]

Interactions[edit]

CSNK1E has been shown to interact with PER1[4] and AXIN1.[5]

Inhibitors[edit]

Selective
Non-selective
  • PF-670462 (also inhibits CK1-δ)

References[edit]

  1. ^ Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465. 
  2. ^ Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983Freely accessible. PMID 10535959. 
  3. ^ "Entrez Gene: CSNK1E casein kinase 1, epsilon". 
  4. ^ Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM (Jul 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology. 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. PMC 85940Freely accessible. PMID 10848614. 
  5. ^ Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395. 

External links[edit]