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Aliases CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4
External IDs MGI: 2153093 HomoloGene: 20445 GeneCards: CSPG4
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CSPG4
Genomic location for CSPG4
Band 15q24.2 Start 75,674,322 bp[1]
End 75,712,848 bp[1]
RNA expression pattern
PBB GE CSPG4 204736 s at fs.png

PBB GE CSPG4 214297 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 75.67 – 75.71 Mb Chr 15: 56.87 – 56.9 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[5][6][7]

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173546 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032911 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A. 93 (18): 9710–5. PMC 38494Freely accessible. PMID 8790396. doi:10.1073/pnas.93.18.9710. 
  6. ^ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. PMID 16407841. doi:10.1038/sj.onc.1209319. 
  7. ^ a b "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4". 

Further reading[edit]

External links[edit]