CSPG4

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CSPG4
Identifiers
Aliases CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4
External IDs MGI: 2153093 HomoloGene: 20445 GeneCards: 1464
RNA expression pattern
PBB GE CSPG4 204736 s at tn.png

PBB GE CSPG4 214297 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001897

NM_139001

RefSeq (protein)

NP_001888.2

NP_620570.2

Location (UCSC) Chr 15: 75.67 – 75.71 Mb Chr 9: 56.87 – 56.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[3][4][5]

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A. 93 (18): 9710–5. doi:10.1073/pnas.93.18.9710. PMC 38494free to read. PMID 8790396. 
  4. ^ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841. 
  5. ^ a b "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4". 

Further reading[edit]