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Cystatin SN
Symbol CST1
External IDs OMIM123855 HomoloGene88653 GeneCards: CST1 Gene
RNA expression pattern
PBB GE CST1 206224 at tn.png
PBB GE CST1 206994 at tn.png
More reference expression data
Species Human Mouse
Entrez 1469 n/a
Ensembl ENSG00000170373 n/a
UniProt P01037 n/a
RefSeq (mRNA) NM_001898 n/a
RefSeq (protein) NP_001889 n/a
Location (UCSC) Chr 20:
23.75 – 23.75 Mb
PubMed search [1] n/a

Cystatin-SN is a protein that in humans is encoded by the CST1 gene.[1]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.[1]


External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I25.010

Further reading[edit]