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For the TC LID CST5, see Sable Island § Sable Island station.
Protein CST5 PDB 1rn7.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CST5
External IDs MGI: 1930004 HomoloGene: 55615 GeneCards: CST5
RNA expression pattern
PBB GE CST5 207925 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 23.88 – 23.88 Mb Chr 2: 149.41 – 149.41 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Cystatin-D is a protein that in humans is encoded by the CST5 gene.[3][4]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Freije JP, Abrahamson M, Olafsson I, Velasco G, Grubb A, Lopez-Otin C (Dec 1991). "Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor". J Biol Chem. 266 (30): 20538–43. PMID 1939105. 
  4. ^ a b "Entrez Gene: CST5 cystatin D". 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I25.005

Further reading[edit]