CST8 (gene)

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CST8
Identifiers
Aliases CST8, CRES, CTES5, cystatin 8
External IDs MGI: 107161 HomoloGene: 4011 GeneCards: CST8
RNA expression pattern
PBB GE CST8 220627 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001281730
NM_005492

NM_009978

RefSeq (protein)

NP_001268659
NP_005483

NP_034108.1
NP_034108

Location (UCSC) Chr 20: 23.49 – 23.5 Mb Chr 2: 148.8 – 148.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cystatin-8 is a protein that in humans is encoded by the CST8 gene.[3][4]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Cornwall GA, Hann SR (Aug 1995). "Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation". Mol Reprod Dev. 41 (1): 37–46. doi:10.1002/mrd.1080410107. PMID 7619504. 
  4. ^ a b "Entrez Gene: CST8 cystatin 8 (cystatin-related epididymal specific)". 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I25.027

Further reading[edit]

External links[edit]