CSTF1

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CSTF1
Identifiers
Aliases CSTF1, CstF-50, CstFp50, cleavage stimulation factor subunit 1
External IDs MGI: 1914587 HomoloGene: 1012 GeneCards: CSTF1
RNA expression pattern
PBB GE CSTF1 202190 at fs.png

PBB GE CSTF1 32723 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033521
NM_001033522
NM_001324

NM_024199

RefSeq (protein)

NP_001028693
NP_001028694
NP_001315

NP_077161.1
NP_077161

Location (UCSC) Chr 20: 56.39 – 56.41 Mb Chr 2: 172.37 – 172.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.[3][4][5]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[5]

Interactions[edit]

CSTF1 has been shown to interact with BARD1.[4][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Takagaki Y, Manley JL (Dec 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J Biol Chem. 267 (33): 23471–4. PMID 1358884. 
  4. ^ a b Kleiman FE, Manley JL (Mar 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228. 
  5. ^ a b "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa". 
  6. ^ Kleiman, F E; Manley J L (Sep 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. UNITED STATES. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523. 

External links[edit]

Further reading[edit]