CSTF2

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CSTF2
Protein CSTF2 PDB 1p1t.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSTF2, CstF-64, cleavage stimulation factor subunit 2
External IDsOMIM: 300907 MGI: 1343054 HomoloGene: 80171 GeneCards: CSTF2
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for CSTF2
Genomic location for CSTF2
BandXq22.1Start100,820,359 bp[1]
End100,840,932 bp[1]
RNA expression pattern
PBB GE CSTF2 204459 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001306206
NM_001306209
NM_001325

NM_001290398
NM_001290399
NM_133196
NM_001359053
NM_001359054

RefSeq (protein)

NP_001293135
NP_001293138
NP_001316
NP_001293135.1

NP_001277327
NP_001277328
NP_573459
NP_001345982
NP_001345983

Location (UCSC)Chr X: 100.82 – 100.84 MbChr X: 134.06 – 134.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.[5][6]

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.[6]

Interactions[edit]

CSTF2 has been shown to interact with CSTF3,[7] SUB1,[8] SYMPK,[7] BARD1[9][10] and BRCA1.[9][10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101811 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031256 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7. Bibcode:1992PNAS...89.1403T. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
  6. ^ a b "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".
  7. ^ a b Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.
  8. ^ Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848.
  9. ^ a b Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228.
  10. ^ a b Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.

External links[edit]

Further reading[edit]