CSTF3

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CSTF3
Protein CSTF3 PDB 2ond.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSTF3, CSTF-77, cleavage stimulation factor subunit 3
External IDsMGI: 1351825 HomoloGene: 1014 GeneCards: CSTF3
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CSTF3
Genomic location for CSTF3
Band11p13Start33,077,188 bp[1]
End33,162,371 bp[1]
RNA expression pattern
PBB GE CSTF3 203947 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033505
NM_001033506
NM_001326

NM_001037326
NM_145529
NM_177253

RefSeq (protein)

NP_001028677
NP_001028678
NP_001317

NP_001032403
NP_663504
NP_796227

Location (UCSC)Chr 11: 33.08 – 33.16 MbChr 2: 104.59 – 104.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.[5][6]

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

Interactions[edit]

CSTF3 has been shown to interact with CSTF2.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176102 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027176 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Takagaki Y, Manley JL (December 1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4. Bibcode:1994Natur.372..471T. doi:10.1038/372471a0. PMID 7984242.
  6. ^ a b "Entrez Gene: CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa".
  7. ^ Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.

External links[edit]

Further reading[edit]