CTPS2

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CTPS2
Protein CTPS2 PDB 2V4U.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CTPS2, CTP synthase 2
External IDs MGI: 1933185 HomoloGene: 115908 GeneCards: CTPS2
RNA expression pattern
PBB GE CTPS2 219080 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144002
NM_019857
NM_175859

NM_001168568
NM_001168569
NM_001168571
NM_018737

RefSeq (protein)

NP_001137474
NP_062831
NP_787055

Location (UCSC) Chr X: 16.59 – 16.71 Mb Chr X: 162.9 – 163.03 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene.[3][4]

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ van Kuilenburg AB, Meinsma R, Vreken P, Waterham HR, van Gennip AH (Oct 2000). "Identification of a cDNA encoding an isoform of human CTP synthetase". Biochim Biophys Acta. 1492 (2–3): 548–52. doi:10.1016/s0167-4781(00)00141-x. PMID 10899599. 
  4. ^ a b "Entrez Gene: CTPS2 CTP synthase II". 

External links[edit]

Further reading[edit]